Program Operations Manual System (POMS)
TN 54 (09-22)
DI 23022.221 Liposarcoma - Metastatic or Recurrent
COMPASSIONATE ALLOWANCES INFORMATION
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LIPOSARCOMA
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ALTERNATE NAMES
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Dedifferentiated Liposarcoma; Pleomorphic Liposarcoma; Inflammatory Liposarcoma; Spindle
Cell Liposarcoma; Myxoid Liposarcoma
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DESCRIPTION
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Liposarcoma is a tumor that arises from fat tissue. The exact cause of liposarcoma is unknown
but probably is related to genetic mutations. This tumor most often occurs in the
extremities, but can be found in other parts of the body. Liposarcomas occur in tissue
that is elastic and easily moved causing the tumors to exist a long time before symptoms
become evident. Liposarcomas may start out as benign tumors, but later become malignant
tumors and grow into surrounding tissues or organs. The most common subtypes of liposarcomas
are well-differentiated, myxoid, pleomorphic, and dedifferentiated. Liposarcoma that
is metastatic or recurrent is considered an aggressive tumor because it often spreads
to other parts of the body. Some subtypes are prone to metastasis or recurrence. For
example, distant metastases occur in nearly half of pleomorphic liposarcomas; recurrence
in about 40% of dedifferentiated liposarcomas.
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DIAGNOSTIC TESTING, PHYSICAL FINDINGS, AND ICD-9-CM/ICD-10-CM CODING
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Diagnostic testing:
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X-ray or MRI of the affected areas; and
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Histologic examination of tissue by needle or surgical biopsy.
Physical findings: People with a liposarcoma may present with:
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Painless swelling or a mass on the body that tends to be large, firm, and near underlying
structures;
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Pain or soreness caused by compressed nerves or muscles;
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Limping or difficulties using the legs, feet, arms or hands; and
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Reduced range of motion in the affected areas.
ICD-9: 171.X Depends on the location of the tumor
ICD-10: C80.1
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PROGRESSION
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Liposarcomas most often occur in people between the ages of 40 years of age to 60
years of age. It may also occur in children during the teenage years. The prognosis
of liposarcoma varies and is based on the size, location, and recurrence of the tumors.
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TREATMENT
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The treatment for liposarcoma depends on the type, size, and location of the tumor,
recurrence, and spread (metastasis) of the tumor. A combination of surgery and radiation
therapy is most often used.
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SUGGESTED PROGRAMMATIC ASSESSMENT*
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Suggested MER for Evaluation:
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Clinical history and examination that describes the diagnostic features of the impairment;
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Suggested Listings for Evaluation:
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DETERMINATION
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LISTING
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REMARKS
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Meets
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13.04 A or B
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Regional or distant metastases meets 13.04 A; recurrent disease meets 13.04 B.
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113.03
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Equals
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* Adjudicators may, at their discretion, use the Medical Evidence of Record or the
listings suggested to evaluate the claim. However, the decision to allow or deny the
claim rests with the adjudicator.
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