Diagnostic testing: Diagnostic testing for Mastocytosis Type IV includes:
• Skin exam;
• Bone marrow biopsy;
• Plasma tryptase; and
• Urine mediators such as histamine.
Imaging testing can include skeletal survey and gastrointestinal evaluation. Bone
scans and bone marrow testing are conclusive.
Physical findings: Signs and symptoms of this condition include:
• Anemia and bleeding disorders;
• Gastrointestinal symptoms such as abdominal pain, diarrhea, nausea, or vomiting;
• Itching, hives, or flushing of the skin;
• Anaphylactoid reactions;
• Enlarged liver (hepatomegaly);
• Enlarged spleen (splenomegaly); and
• Enlarged lymph nodes (lymphadenopathy).