TN 30 (08-20)

DI 23022.949 Fatal Familial Insomnia

COMPASSIONATE ALLOWANCE INFORMATION

FATAL FAMILIAL INSOMNIA

ALTERNATE NAMES

Insomnia Fatal Familial; FFI

DESCRIPTION

Fatal Familial Insomnia (FFI) is a rare, genetic sleep disorder caused by prion mutation of the PRNP gene. These mutations lead to degeneration in the thalamus, the part of the brain responsible for sensory perception and regulation of motor function. FFI is characterized by by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.

DIAGNOSTIC TESTING, PHYSICAL FINDINGS, AND ICD-9-CM/ICD-10-CM CODING

Diagnostic testing:

  • Electroencephalography (EEG);

  • Magnetic resonance imaging (MRI) of the brain;

  • Sleep apnea testing; and

  • Evidence of mutations in the PRNP gene.

Physical findings:

  • Difficulty sleeping;

  • High pulse and blood pressure;

  • Excessive sweating; and

  • Decline in coordination and motor ability.

ICD-9: 046.72

ICD-10: A81.83

PROGRESSION

FFI is a progressive sleep disorder that usually begins in adulthood and leads to death within 6 to 32 months.

TREATMENT

There is no cure for FFI. Treatment is symptomatic and palliative.

SUGGESTED PROGRAMMATIC ASSESSMENT*

Suggested MER for Evaluation:

  • Clinical history and examination that describes the diagnostic features of this impairment; and

  • Appropriate laboratory testing, including genetic testing showing mutations in the PRNP gene.

Suggested Listings for Evaluation:

DETERMINATION

LISTING

REMARKS

Meets

11.17

Equals

* Adjudicators may, at their discretion, use the Medical Evidence of Record or the listings suggested to evaluate the claim. However, the decision to allow or deny the claim rests with the adjudicator.

To Link to this section - Use this URL:
http://policy.ssa.gov/poms.nsf/lnx/0423022949
DI 23022.949 - Fatal Familial Insomnia - 08/20/2020
Batch run: 08/20/2020
Rev:08/20/2020