1. These listings are examples of impairments that commonly affect multiple body systems
and that we consider significant enough to result in marked and severe functional
limitations. If your severe impairment(s) does not meet the criteria of any of these
listings, we must also consider whether your impairment(s) meets the criteria of a
listing in another body system.
2. There are many other impairments that can cause deviation from, or interruption
of, the normal function of the body or interfere with development; for example, congenital
anomalies, chromosomal disorders, dysmorphic syndromes, metabolic disorders, and perinatal
infectious diseases. In these impairments, the degree of deviation or interruption
may vary widely from child to child. Therefore, the resulting functional limitations
and the progression of those limitations are more variable than with the catastrophic
congenital abnormalities and diseases we include in these listings. For this reason,
we evaluate the specific effects of these impairments on you under the listing criteria
in any affected body system(s) on an individual case basis. Examples of such impairments
include, but are not limited to, triple X syndrome (XXX syndrome), fragile X syndrome,
phenylketonuria (PKU), caudal regression syndrome, and fetal alcohol syndrome.
3. If you have a severe medically determinable impairment(s) that does not meet a
listing, we will consider whether your impairment(s) medically equals a listing. If
your impairment(s) does not meet or medically equal a listing, we will consider whether
it functionally equals the listings. (See §§404.1526, 416.926, and 416.926a.) When
we decide whether you continue to be disabled, we use the rules in §416.994a.
110.01 Category of Impairments, Impairments That Affect Multiple Body Systems
110.06 Non-mosaic Down syndrome, established as described in 110.00B.
110.08 A catastrophic congenital abnormality or disease, established as described
in 110.00B, and:
A. Death usually is expected within the first months of life, and the rare individuals
who survive longer are profoundly impaired (for example, anencephaly, trisomy 13 or
B. That interferes very seriously with development; for example, cri du chat syndrome
(deletion 5p syndrome) or Tay-Sachs disease (acute infantile form)