TN 21 (12-18)

DI 23022.700 Child Lymphoma

COMPASSIONATE ALLOWANCE INFORMATION

CHILD LYMPHOMA

ALTERNATE NAMES

Childhood Non-Hodgkin Lymphoma; Pediatric Non-Hodgkin Lymphoma; Diffuse Large B-cell Lymphoma; B-cell Lymphoma; T-cell Lymphoma; Peripheral T-cell Lymphoma; Follicular Lymphoma; Burkitt Lymphoma; Anaplastic Large Cell Lymphoma; Hodgkin Lymphoma; Hodgkin Disease; Pediatric Hodgkin Lymphoma; Classical Hodgkin Lymphoma; Nodular Lyphocyte-Predominant Hodgkin Lymphoma

DESCRIPTION

Cancer cells that start in the lymphatic systems are called lymphomas. When cancer cells get into the lymphatic system, the cancerous cells can also spread to other organs and tissues in the body. Child Lymphoma is the third most common cancer in children. Most childhood lymphomas can be classified as one of the following four types:

• Burkitt lymphoma (BL), or small noncleaved cell lymphoma (SNCCL);

• Lymphoblastic lymphoma (LL) - adjudicators are reminded that lymphoblastic lymphoma is a type of lymphoma that is similar to acute leukemia and needs to be evaluated under listing 13.06;

• Diffuse large B-cell lymphoma (DLBCL); and

• Anaplastic large cell lymphoma (ALDL)

DIAGNOSTIC TESTING, PHYSICAL FINDINGS, AND ICD-9-CM CODING

Diagnostic testing: Diagnostic testing for child lymphoma includes:

• Physical examination;

• Blood and urine tests;

• Lymph node biopsy;

• Bone marrow aspirate and biopsy;

• Lumbar puncture;

• Removal of fluid from chest or abdomen for testing;

• X-rays;

• Ultrasound;

• Radionuclide bone scan; and

• MRI, CT, and PET scan.

Physical findings: Signs of childhood lymphoma may include:

• Breathing problems;

• Swollen lymph nodes;

• Wheezing;

• Coughing;

• Swelling of the head, neck, upper body or arms;

• Experience difficulties swallowing;

• Painless swelling of the lymph nodes in the neck, underarm, stomach or groin;

• Unexplained weight loss;

• Night sweats; and

• Fever.

Childhood lymphoma may cause many different signs and symptoms, depending on the location of the tumors.

• Lymphoma that grows close to the surface of the body (sides of the neck, underarm area above the collarbone or in the groin area) may have enlarged nodes that are seen or felt as in lumps under the skin.

• Lymphoma that is in the abdomen area will cause it to become swollen and tender.

• Lymphoma that starts in the thymus gland or lymph nodes of the chest or near the windpipe (trachea) may cause swelling and a bluish-red skin color.

ICD-9: 200.2; 200.5; 200.6; 200.7; 202.0; 202.7; 202.8

PROGRESSION

Lymphoma is usually a disease of rapid onset and progression. Although the prognosis greatly depends on histology, extent of the disease, presence or absence of metastasis; the child’s age; and response to therapy, the majority of children with newly diagnosed child lymphoma are considered to have an excellent prognosis. Children with recurrent lymphoma have a less favorable prognosis and require longer treatment. Children with lymphoma that involves the brain, spinal cord, bone marrow, liver or lung are also associated with a less favorable prognosis. If the child does not respond to chemotherapy drugs, the disease can cause rapid death.

TREATMENT

By the time that a child is diagnosed with recurrent lymphoma, the lymphoma has spread to other parts of the body. Most children with recurrent lymphoma are treated with chemotherapy. Chemotherapy is the most important treatment for children with lymphoma because chemotherapy can reach all parts of the body and kill lymphoma cells wherever they may be. It is common to use a combination of drugs and treatment, including intrathecal therapy (injection of chemotherapy into the spinal fluid), that may last a number of months or years.

SUGGESTED PROGRAMMATIC ASSESSMENT*

Suggested MER for Evaluation:

• Clinical history and examination that describes the diagnostic features of the impairment;

• Pathology/biopsy report of the cancer; and

• CT scan, MRI scan, or ultrasound reports.

Suggested Listings for Evaluation:

DETERMINATION

LISTING

REMARKS

Meets

113.05 A 1

Primary lymphoma (excluding lymphoblastic) which involves brain, spinal cord, bone marrow, liver, or lung meets the criteria in listing 113.05 A 1 for non-Hodgkin lymphoma and Hodgkin lymphoma.

113.05 A 2

Recurrent or persistent lymphoma regardless of location, following initial treatment meets the criteria in listing113.05 A 2, for non-Hodgkin lymphoma and Hodgkin lymphoma.

113.05 B 1

Primary lymphoma (excluding lymphoblastic) which involves brain, spinal cord, bone marrow, liver, or lung meets the criteria in listing and 113.05 B 1 for non-Hodgkin lymphoma and Hodgkin lymphoma.
113.05 B 2 Recurrent or persistent lymphoma regardless of location, following initial treatment meets the criteria in listing 113.05 B 2, for non-Hodgkin lymphoma and Hodgkin lymphoma.

Equals

* Adjudicators may, at their discretion, use the Medical Evidence of Record or the listings suggested to evaluate the claim. However, the decision to allow or deny the claim rests with the adjudicator.

To Link to this section - Use this URL:
http://policy.ssa.gov/poms.nsf/lnx/0423022700
DI 23022.700 - Child Lymphoma - 12/28/2018
Batch run: 12/28/2018
Rev:12/28/2018