TN 22 (12-18)

DI 23022.987 Transplant Coronary Artery Vasculopathy

COMPASSIONATE ALLOWANCE INFORMATION

TRANSPLANT CORONARY ARTERY VASCULOPATHY

ALTERNATE NAMES

Transplant Cardiac Allograft Vasculopathy; Cardiac Transplant Vasculopathy

DESCRIPTION

Cardiac transplantation is a type of therapy used in the treatment of end-stage heart failure. Transplant Coronary Artery Vasculopathy (CAV) is the second most common cause of death after malignancy for individuals receiving a cardiac transplant.

Cardiac denervation at the time of heart transplantation usually prevents transplant patients from experiencing angina which is an important warning sign for heart disease. Because of this lack of early clinical symptoms, transplant patients with CAV typically present late with silent myocardial infarction, loss of allograft function or sudden death.

Due to diffuse nature of intimal thickening in CAV, coronary angiography is not as sensitive and accurate as it is in native coronary artery disease (CAD).

DIAGNOSTIC TESTING, PHYSICAL FINDINGS, AND ICD-9-CM CODING

Diagnostic testing:

• Intravascular ultrasonography (IVUS) is used to detect early coronary artery vasculopathy;

• Coronary angiogram;

• Dobutamine stress echocardiography;

• Single proton emission CT (SPECT); and

• Multidetector CT.

Physical findings:

• Heart failure;

• Dangerous changes in heart rhythm (arrhythmias);

• Sudden cardiac arrest;

• Non-specific graft failure;

• Multi-organ failure;

• Acute rejection;

• Infection;

• Generalized swelling (edema);

• General discomfort or ill feeling; and

• Pain or swelling in the chest close to the heart.

Immunosuppressive medications such as cyclosporine and corticosteroids that are used to treat transplant CAV, may contribute to endothelial cell injury and intimal hyperplasia (thickening of inner lining of coronary artery walls).

ICD-9: 414.06; 414.07

PROGRESSION

Although the progression of transplant CAV is variable, generally the course is progressive with limited therapeutic options.

TREATMENT

The disease process of transplant coronary artery vasculopathy is progressive and generally unresponsive to treatment. Revascularization is effective palliative therapy; retransplantation offers a more definitive solution but is limited by organ shortages.

SUGGESTED PROGRAMMATIC ASSESSMENT*

Suggested MER for Evaluation:

  • Clinical history and examination that describes the diagnostic features of the impairment;

  • Cardiology consultation reports; and

  • Imaging studies of the heart and blood laboratory testing.

Suggested Listings for Evaluation:

DETERMINATION

LISTING

REMARKS

Meets

4.02

Listing level severity must be documented.

4.04

Listing level severity must be documented.

4.05

Listing level severity must be documented.

Equals

* Adjudicators may, at their discretion, use the Medical Evidence of Record or the listings suggested to evaluate the claim. However, the decision to allow or deny the claim rests with the adjudicator.

 


To Link to this section - Use this URL:
http://policy.ssa.gov/poms.nsf/lnx/0423022987
DI 23022.987 - Transplant Coronary Artery Vasculopathy - 12/28/2018
Batch run: 12/28/2018
Rev:12/28/2018